316802

antibody from BioLegend

Targeting: CD226 DNAM-1, DNAM1, PTA1, TLiSA1

Immunoprecipitation (Recommended by provider)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

316802

Provider

BioLegend

Product name

Purified anti-human CD226 (DNAM-1)

Antibody type

Monoclonal

Antigen

Human cytotoxic T lymphocytes

Description

CD226 is a 65 kD type I transmembrane glycoprotein, known as DNAM-1 (DNAX accessory molecule-1), PTA1(platelet and T cell activation antigen 1), or TLiSA1 (T lineage-specific activation antigen 1 antigen). It belongs to the immunoglobulin superfamily containing 2 Ig-like domain and is expressed on majority of T lymphocytes, NK cells, monocytes, and platelets as well as a subset of B cells and activated endothelial cells. DNAM-1 is also expressed on CD8+ (but not CD8-) dendritic cells in mouse model. CD226 is an adhesion molecule involved in CTL and NK cell-mediated cytotoxicity. It has been identified that CD155 (poliovirus receptor, PVR) and CD112 (nectin-2, PRR-2) are CD226 ligands. DX11 antibody is able to inhibit CTL and NK cell-mediated cytotoxicity, and to block T cell cytokine production.

Reactivity

Human, Simian

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C.