BS60752

antibody from Bioworld Technology, Inc
Targeting: TMPRSS15 ENTK, MGC133046, PRSS7
Provider product page for BS60752

Antibody data

Product number
BS60752 - Provider product page
Provider
Bioworld Technology, Inc
Product name
TMPRSS15 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human TMPRSS15
Description
Enterokinase, also known as enteropeptidase or serine protease 7, belongs to the peptidase S1 family and localizes to the intestinal brush border in the proximal small intestine. It exists as a heterodimer of a catalytic light chain (LC) and a non-catalytic heavy chain (HC) linked together by a disulfide bond. Enterokinase HC plays a role in macromolecular substrate recognition and specificity. Duodenase is the serine protease responsible for the release and activation of Enterokinase from its inactive precursor. Active Enterokinase recognizes the target sequence, Asp-Asp-Asp-Asp-Lys, and is responsible for catalyzing the conversion of pancreatic trypsinogen to activated trypsin. Activated trypsin then further activates digestive enzymes such as chymotrypsin, carboxypeptidases, elastases and lipases, releasing them from their inactive precursors. Enterokinase is important for proper digestion of proteins. Improper functioning of Enterokinase may result in congenital enteropeptidase deficiency. This recessively inherited disorder leads to severe protein malabsorption and can result in low serum protein, chronic diarrhea and, in infants, a failure to thrive.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TMPRSS15 protein structure - BS60752 shown in red.