367303

antibody from BioLegend
Targeting: APCDD1 B7323
Provider product page for 367303

Antibody data

Product number
367303 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#367303, RRID:AB_2565750
Product name
PE anti-human APCDD1 (DRAPC1)
Antibody type
Monoclonal
Antigen
Human APCDD1-His.
Description
APCDD1 (adenomatosis polyposis coli down-regulated 1), also known as B7323, DRAPC1, or FP7019, is a 514 amino acid single-pass type I membrane protein. APCDD1 is expressed in the gastrointestinal track, placental trophoblasts, and both epidermal and dermal compartments from human hair follicles. It is also weakly expressed in lymphoid tissues. APCDD1 has been reported to be directly regulated by the beta-catenin/ITF-2 complex and that its elevated expression promotes the proliferation of colonic epithelial cells. It is thought to function as a developmental target of the beta-catenin pathway and may play an important role in colorectal tumorigenesis. Recently, it was found to negatively regulate Wnt signaling in a cell-autonomous manner.
Reactivity
Human
Host
Mouse
Conjugate
Yellow dye
Antibody clone number
7.13
Vial size
25 tests
Storage
2°C-8°C
Handling
Ambient RT
APCDD1 protein structure - 367303 shown in red.