Tissue expression
Cell line expression
Protein structure
AFF1
AF4/FMR2 family member 1AF-4, AF4, MLLT2, PBM1
This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Top validated antibodies |
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Novus Biologicals | NBP1-28728 | 1 references | Polyclonal |
WB
IP
IHC
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FineTest Biotech | FNab00195 | Polyclonal |
WB
EL
ICC
IHC |
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LSBio | LS-C354031 | Polyclonal |
WB
IHC |
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Biorbyt | orb2212501 | Polyclonal |
WB
ICC
IP
IHC |
||
Boster Biological Technology | A02590 | Polyclonal |
WB
ICC
IHC
|
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