ICE2

This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]

Description

Interactor of little elongation complex ELL subunit 2

Tissue specificity

Tissue enhanced (parathyroid gland)

Subcell location

Nucleoplasm, Nuclear bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (60419609 - 60479160)

Ensembl ID

ENSG00000128915  (ver. 103.38)

Orthologs

Mouse Ice2: ENSMUSG00000032235

UniProt

Q659A1

neXtProt

NX_Q659A1

Human splice variants
Mouse splice variants

Protein structure