BPIFA2

This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds bacterial lipopolysaccharide (LPS) and inhibits bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Description

BPI fold containing family A member 2

Tissue specificity

Tissue enriched (salivary gland)

Predicted location

Secreted to digestive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (33161768 - 33181412)

Ensembl ID

ENSG00000131050  (ver. 103.38)

Orthologs

Mouse Bpifa2: ENSMUSG00000042459

UniProt

Q96DR5

neXtProt

NX_Q96DR5

Human splice variants
Mouse splice variants

Protein structure