WDR83

This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Description

WD repeat domain 83

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Vesicles, Centriolar satellite

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (12666802 - 12675832)

Ensembl ID

ENSG00000123154  (ver. 103.38)

Orthologs

Mouse Wdr83: ENSMUSG00000005150

UniProt

Q9BRX9

neXtProt

NX_Q9BRX9

Human splice variants
Mouse splice variants

Protein structure