BS8381

antibody from Bioworld Technology, Inc

Targeting: RECK hRECK, ST15

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8381

Provider

Bioworld Technology, Inc

Product name

RECK polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human RECK.

Description

RECK (reversion-inducing-cysteine-rich protein with Kazal motifs) is a membrane anchored glycoprotein that binds to and inhibits the proteolytic activity of matrix metalloproteinase-9 (MMP-9) . The enzymatic activity of MMP-9 facilitates tumor invasion by proteolytically digesting the extracellular matrix, thereby enabling tumor growth, expansion and metastasis . RECK inhibits the secretion and activation of MMP-9 into the extracellular matrix, which results in the inhibition of tumor growth. RECK contains multiple EGF-like repeats and serine-protease inhibitor-like domains. The expression of RECK is suppressed in several tumors and oncogenically transformed cells, suggesting that the loss of RECK activity correlates with transformed phenotypes . Transcriptional activation of RECK is potentially negatively regulated by the Sp1 family of transcription factors, as it contains two Sp1 binding motifs in the promoter region, and, in cells transformed with the ras oncogene, the Sp1 promoter region is essential for repressing RECK gene expression.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.