AF921

antibody from R&D Systems

Targeting: BAMBI NMA

Western blot (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

AF921

Provider

R&D Systems

Product name

Human BAMBI/NMA Antibody

Antibody type

Polyclonal

Description

Antigen Affinity-purified. Detects human BAMBI/NMA in direct ELISAs and Western blots.

Reactivity

Human

Host

Goat

Conjugate

Unconjugated

Antigen sequence

Q13145


Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

BAMBI regulates macrophages inducing the differentiation of Treg through the TGF-β pathway in chronic obstructive pulmonary disease.

Sun SW, Chen L, Zhou M, Wu JH, Meng ZJ, Han HL, Miao SY, Zhu CC, Xiong XZ
Respiratory research 2019 Feb 6;20(1):26

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C-terminal-truncated HBV X promotes hepato-oncogenesis through inhibition of tumor-suppressive β-catenin/BAMBI signaling.

Lee S, Lee MJ, Zhang J, Yu GR, Kim DG
Experimental & molecular medicine 2016 Dec 2;48(12):e275

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TGF-β/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease.

Zhang JC, Chen G, Chen L, Meng ZJ, Xiong XZ, Liu HJ, Jin Y, Tao XN, Wu JH, Sun SW
Scientific reports 2016 Aug 23;6:31911

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Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors.

Luo X, Hutley LJ, Webster JA, Kim YH, Liu DF, Newell FS, Widberg CH, Bachmann A, Turner N, Schmitz-Peiffer C, Prins JB, Yang GS, Whitehead JP
Diabetes 2012 Jan;61(1):124-36

Immunohistochemistry

Supportive validation

Submitted by

R&D Systems (provider)

Main image

Experimental details

BAMBI/NMA in Human Kidney. BAMBI/NMA was detected in immersion fixed paraffin-embedded sections of human kidney using Goat Anti-Human BAMBI/NMA Antigen Affinity-purified Polyclonal Antibody (Catalog # AF921) at 3 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in tubular epithelial cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.