BS61196
antibody from Bioworld Technology, Inc
Targeting: GADD45GIP1
CKBBP2, CKbetaBP2, CRIF1, MGC4667, MGC4758, PLINP-1, Plinp1, PRG6
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- BS61196 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- GADD45GIP1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human GADD45GIP1.
- Description
- CRIF1, also known as GADD45GIP1, PLINP1, PRG6 or CKBBP2, is a 222 amino acid nuclear protein that plays a role in apoptosis control. Expressed in a variety of tissues, including heart, thyroid, trachea, kidney, ovary, pancreas, testis and stomach, CRIF1 functions as a negative regulator of G1 to S phase cell cycle production, specifically by working with GADD 45 proteins to inhibit the activity of cyclin-dependent kinases (Cdks). While overexpression of CRIF1 results in cell cycle arrest at the G1 phase, downregulation of CRIF1 by p53 in apoptotic cells promotes cell cycle progression and may be an important factor in tumor growth and metastasis. CRIF1 is subject to phosphorylation by casein kinase II, an event that is thought to decrease CRIF1 activity and promote cellular proliferation. Human CRIF1 shares 90% homology with its mouse counterpart, suggesting a conserved role between species.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
No comments: Submit comment
Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of GADD45GIP1 pAb at 1:500 dilution Line1:Hela whole cell lysateLine2:PC12 whole cell lysateLine3:sp20 whole cell lysate