COLEC11

This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Description

Collectin subfamily member 11

Tissue specificity

Tissue enhanced (gallbladder, liver)

Predicted location

Intracellular, Secreted to blood

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (3594832 - 3644644)

Ensembl ID

ENSG00000118004  (ver. 103.38)

Orthologs

Mouse Colec11: ENSMUSG00000036655

UniProt

Q9BWP8

neXtProt

NX_Q9BWP8

Human splice variants
Mouse splice variants

Protein structure