PRSS12

This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017]

Description

Serine protease 12

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Actin filaments

Predicted location

Secreted - unknown location

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Potential drug targets
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

4 (118280038 - 118353003)

Ensembl ID

ENSG00000164099  (ver. 103.38)

Orthologs

Mouse Prss12: ENSMUSG00000027978

UniProt

P56730

neXtProt

NX_P56730

Human splice variants
Mouse splice variants

Protein structure