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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Western blot [1]
- Immunohistochemistry [3]
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- Product number
- NBP1-81392 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-81392, RRID:AB_11021780
- Product name
- Rabbit Polyclonal METTL14 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human METTL14 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references m6A modification controls the innate immune response to infection by targeting type I interferons.
Dynamic m(6)A mRNA methylation directs translational control of heat shock response.
N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.
N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells.
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Winkler R, Gillis E, Lasman L, Safra M, Geula S, Soyris C, Nachshon A, Tai-Schmiedel J, Friedman N, Le-Trilling VTK, Trilling M, Mandelboim M, Hanna JH, Schwartz S, Stern-Ginossar N
Nature immunology 2019 Feb;20(2):173-182
Nature immunology 2019 Feb;20(2):173-182
Dynamic m(6)A mRNA methylation directs translational control of heat shock response.
Zhou J, Wan J, Gao X, Zhang X, Jaffrey SR, Qian SB
Nature 2015 Oct 22;526(7574):591-4
Nature 2015 Oct 22;526(7574):591-4
N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.
Liu N, Dai Q, Zheng G, He C, Parisien M, Pan T
Nature 2015 Feb 26;518(7540):560-4
Nature 2015 Feb 26;518(7540):560-4
N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells.
Wang Y, Li Y, Toth JI, Petroski MD, Zhang Z, Zhao JC
Nature cell biology 2014 Feb;16(2):191-8
Nature cell biology 2014 Feb;16(2):191-8
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C
Nature chemical biology 2014 Feb;10(2):93-5
Nature chemical biology 2014 Feb;10(2):93-5
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Simple Western: METTL14 Antibody [NBP1-81392] - Simple Western lane view shows a specific band for METTL14 in 0.2 mg/ml of NIH-3T3 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: METTL14 Antibody [NBP1-81392] - Staining of human kidney shows moderate to strong nuclear positivity in glomeruli and cells in tubules.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: METTL14 Antibody [NBP1-81392] - Immunohistochemical staining of human testis shows moderate to strong nuclear positivity in cells in seminiferous ducts.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: METTL14 Antibody [NBP1-81392] - Staining of human fallopian tube shows strong nuclear positivity in glandular cells.
