CABT-B9154

antibody from Creative Diagnostics

Targeting: CACNA1I Cav3.3

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9154

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human CACNA1I Polyclonal Antibody

Antibody type

Polyclonal

Description

Calcium channel CaV3.3 (a1I) is a low-voltage-activated T-type calcium channel. Such T-type channels are expressed throughout the body. In heart, they may be involved in pacemaker current. In neurons, too, these channels may play a secondary pacemaker role. Three genes encoding T-type Ca2+ channels have been cloned and designated as CaV3.1 (a1G), CaV3.2 (a1H) and CaV3.3 (a1I). While CaV3.1 (a 1G) and CaV3.2 (a1H) are widely expressed in various tissues, CaV3.3 (a1I) is primarily expressed in the central nervous system, where high expression was described in thalamic neurons. The Ca2+ current generated by the CaV3.3 channel displays much slower activation and inactivation compared to the currents produced by CaV3.1 and CaV3.2, suggesting it might play a different role in neuronal excitability.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Concentration

Lot specific

Storage

Store at -20°C, and avoid repeat freeze-thaw cycles.