ATP6V1C2

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008]

Description

ATPase H+ transporting V1 subunit C2

Tissue specificity

Tissue enhanced (epididymis, salivary gland, skin)

Subcell location

Mitochondria

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

2 (10721100 - 10785110)

Ensembl ID

ENSG00000143882  (ver. 103.38)

Orthologs

Mouse Atp6v1c2: ENSMUSG00000020566

UniProt

Q8NEY4

neXtProt

NX_Q8NEY4

Human splice variants
Mouse splice variants

Protein structure