CDIPT

Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Description

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear membrane, Plasma membrane

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (29858357 - 29863414)

Ensembl ID

ENSG00000103502  (ver. 103.38)

Orthologs

Mouse Cdipt: ENSMUSG00000030682

UniProt

O14735

neXtProt

NX_O14735

Human splice variants
Mouse splice variants

Protein structure