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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 11-5867-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Integrin beta 7 Monoclonal Antibody (FIB504), FITC, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The FIB504 monoclonal antibody reacts with human and mouse integrin beta 7. Integrin beta 7 is a 130 kD glycoprotein which associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Main ligands for integrin alpha 4 beta 7 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the main ligand of integrin alpha E beta 7 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. The FIB504 antibody has been reported to have blocking activity.
- Conjugate
- Green dye
- Antibody clone number
- FIB504
- Concentration
- 5 µL/Test
Submitted references A Cdh1-FoxM1-Apc axis controls muscle development and regeneration.
Vitamins A and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells.
Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients.
CD11c+ cells are required for antigen-induced increase of mast cells in the lung.
Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7.
Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection.
Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells.
Engagement of alpha4beta7 integrins by monoclonal antibodies or ligands enhances survival of human eosinophils in vitro.
Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation.
Chen Z, Li L, Xu S, Liu Z, Zhou C, Li Z, Liu Y, Wu W, Huang Y, Kuang M, Fan S, Li H, Li X, Song G, Wu WS, Chen J, Hou Y
Cell death & disease 2020 Mar 9;11(3):180
Cell death & disease 2020 Mar 9;11(3):180
Vitamins A and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells.
Ruiter B, Patil SU, Shreffler WG
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2015 Jul;45(7):1214-25
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2015 Jul;45(7):1214-25
Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients.
Achour A, Baychelier F, Besson C, Arnoux A, Marty M, Hannoun L, Samuel D, Debré P, Vieillard V, K-GREF Study Group
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 1;192(1):503-11
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 1;192(1):503-11
CD11c+ cells are required for antigen-induced increase of mast cells in the lung.
Dahlin JS, Feinstein R, Cui Y, Heyman B, Hallgren J
Journal of immunology (Baltimore, Md. : 1950) 2012 Oct 15;189(8):3869-77
Journal of immunology (Baltimore, Md. : 1950) 2012 Oct 15;189(8):3869-77
Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7.
Monteiro P, Gosselin A, Wacleche VS, El-Far M, Said EA, Kared H, Grandvaux N, Boulassel MR, Routy JP, Ancuta P
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4618-30
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4618-30
Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infection.
Gosselin A, Monteiro P, Chomont N, Diaz-Griffero F, Said EA, Fonseca S, Wacleche V, El-Far M, Boulassel MR, Routy JP, Sekaly RP, Ancuta P
Journal of immunology (Baltimore, Md. : 1950) 2010 Feb 1;184(3):1604-16
Journal of immunology (Baltimore, Md. : 1950) 2010 Feb 1;184(3):1604-16
Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells.
Rodriguez MW, Paquet AC, Yang YH, Erle DJ
BMC immunology 2004 Jul 5;5:13
BMC immunology 2004 Jul 5;5:13
Engagement of alpha4beta7 integrins by monoclonal antibodies or ligands enhances survival of human eosinophils in vitro.
Meerschaert J, Vrtis RF, Shikama Y, Sedgwick JB, Busse WW, Mosher DF
Journal of immunology (Baltimore, Md. : 1950) 1999 Dec 1;163(11):6217-27
Journal of immunology (Baltimore, Md. : 1950) 1999 Dec 1;163(11):6217-27
Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation.
Andrew DP, Berlin C, Honda S, Yoshino T, Hamann A, Holzmann B, Kilshaw PJ, Butcher EC
Journal of immunology (Baltimore, Md. : 1950) 1994 Nov 1;153(9):3847-61
Journal of immunology (Baltimore, Md. : 1950) 1994 Nov 1;153(9):3847-61
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Rat IgG2a K Isotype Control FITC (Product # 11-4321-42) (open histogram) or Anti-Human/Mouse Integrin beta 7 FITC (filled histogram). Cells in the lymphocyte gate were used for analysis.
- Conjugate
- Green dye
