Antibody data
- Antibody Data
- Antigen structure
- References [0]
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- Validations
- Western blot [1]
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- Product number
- BS60337 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- DNER polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human DNER.
- Description
- DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of DNER pAb at 1:500 dilutionLane1:A549 whole cell lysateLane2:Raw264.7 whole cell lysateLane3:PC12 whole cell lysate