502941

antibody from BioLegend
Targeting: TNF DIF, TNF-alpha, TNFA, TNFSF2
Provider product page for 502941
ELISA
Other assay

Antibody data

Product number
502941 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#502941, RRID:AB_2562842
Product name
Purified anti-human TNF-a (MaxPar® Ready)
Antibody type
Monoclonal
Antigen
E. coli-expressed, recombinant human TNF-α
Description
TNF-α is secreted by macrophages, monocytes, neutrophils, T cells (principally CD4+), and NK cells. Many transformed cell lines also secrete TNF-α. Monomeric human TNF-α is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kD. TNF-α forms multimeric complexes; stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been described. TNF-α binding to surface receptors elicits a wide array of biological activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.
Reactivity
Human, Porcine
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
MAb11
Vial size
100 µg
Concentration
1 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
TNF protein structure - 502941 shown in red.