Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations [0]
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- Product number
- 502802 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#502802, RRID:AB_315250
- Product name
- Purified anti-human TNF-
- Antibody type
- Monoclonal
- Antigen
- E. coli-expressed, recombinant human TNF-α
- Description
- TNF-α is secreted by macrophages, monocytes, neutrophils, T-cells (principally CD4+), and NK-cells. Many transformed cell lines also secrete TNF-α. Monomeric human TNF-α is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kD. TNF-α forms multimeric complexes; stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been described. TNF-α binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils. The MAb1 antibody can neutralize the bioactivity of natural or recombinant TNF-α.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving.
Down-regulation of tumor necrosis factor alpha expression by activating transcription factor 2 increases UVC-induced apoptosis of late-stage melanoma cells.
Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 6;109(10):3885-90
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 6;109(10):3885-90
Down-regulation of tumor necrosis factor alpha expression by activating transcription factor 2 increases UVC-induced apoptosis of late-stage melanoma cells.
Ivanov VN, Ronai Z
The Journal of biological chemistry 1999 May 14;274(20):14079-89
The Journal of biological chemistry 1999 May 14;274(20):14079-89
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