GDF7

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]

Description

Growth differentiation factor 7

Tissue specificity

Tissue enhanced (cervix, seminal vesicle)

Subcell location

Vesicles

Predicted location

Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

2 (20667144 - 20679243)

Ensembl ID

ENSG00000143869  (ver. 103.38)

Orthologs

Mouse Gdf7: ENSMUSG00000037660

UniProt

Q7Z4P5

neXtProt

NX_Q7Z4P5

Human splice variants
Mouse splice variants

Protein structure