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- Antibody Data
- Antigen structure
- References [5]
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- Western blot [1]
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- Product number
- MAB2668 - Provider product page
- Provider
- R&D Systems
- Product name
- Human/Mouse/Rat PTP-MEG2 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human, mouse, and rat PTP-MEG2.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
P43378- Isotype
- IgG
- Antibody clone number
- 291835
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells.
miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer.
The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.
Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells.
Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis.
Liu Z, Sun F, Hong Y, Liu Y, Fen M, Yin K, Ge X, Wang F, Chen X, Guan W
Molecular cancer 2017 Jul 26;16(1):133
Molecular cancer 2017 Jul 26;16(1):133
miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer.
Hong Y, Liang H, Uzair-Ur-Rehman, Wang Y, Zhang W, Zhou Y, Chen S, Yu M, Cui S, Liu M, Wang N, Ye C, Zhao C, Liu Y, Fan Q, Zhang CY, Sang J, Zen K, Chen X
Scientific reports 2016 Nov 18;6:37421
Scientific reports 2016 Nov 18;6:37421
The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.
Zhang D, Marlin MC, Liang Z, Ahmad M, Ashpole NM, Sonntag WE, Zhao ZJ, Li G
The Journal of biological chemistry 2016 Nov 11;291(46):23895-23905
The Journal of biological chemistry 2016 Nov 11;291(46):23895-23905
Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells.
Huang X, Gschweng E, Van Handel B, Cheng D, Mikkola HK, Witte ON
Blood 2011 Feb 17;117(7):2157-65
Blood 2011 Feb 17;117(7):2157-65
Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis.
Hao Q, Wang L, Zhao ZJ, Tang H
The Journal of biological chemistry 2009 Jan 9;284(2):799-806
The Journal of biological chemistry 2009 Jan 9;284(2):799-806
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Human/Mouse/Rat PTP-MEG2 by Western Blot. Western blot shows lysates of Raji human Burkitt's lymphoma cell line, TS1 mouse helper T cell line, CTLL-2 mouse cytotoxic T cell line, and Nb2-11 rat lymphoma cell line. PVDF membrane was probed with 1 µg/mL of Human/Mouse/Rat PTP-MEG2 Monoclonal Antibody (Catalog # MAB2668) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PTP-MEG2 at approximately 68 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
