Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 13606-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13606-1-AP, RRID:AB_2104403
- Product name
- FBXO22 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FBXO22 antibody (Cat. #13606-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis.
FBXO22 Suppresses Metastasis in Human Renal Cell Carcinoma via Inhibiting MMP-9-Mediated Migration and Invasion and VEGF-Mediated Angiogenesis.
FBXO22 mediates polyubiquitination and inactivation of LKB1 to promote lung cancer cell growth.
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.
FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21.
Phosphorylation of BACH1 switches its function from transcription factor to mitotic chromosome regulator and promotes its interaction with HMMR.
F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells.
Targeted inhibition of the COP9 signalosome for treatment of cancer.
Quantitative proteome analysis of age-related changes in mouse gastrocnemius muscle using mTRAQ.
Liu P, Cong X, Liao S, Jia X, Wang X, Dai W, Zhai L, Zhao L, Ji J, Ni D, Liu Z, Chen Y, Pan L, Liu W, Zhang J, Huang M, Liu B, Tan M
Cell death and differentiation 2022 Jan;29(1):1-13
Cell death and differentiation 2022 Jan;29(1):1-13
FBXO22 Suppresses Metastasis in Human Renal Cell Carcinoma via Inhibiting MMP-9-Mediated Migration and Invasion and VEGF-Mediated Angiogenesis.
Guo F, Liu J, Han X, Zhang X, Lin T, Wang Y, Bai J, Han J
International journal of biological sciences 2019;15(3):647-656
International journal of biological sciences 2019;15(3):647-656
FBXO22 mediates polyubiquitination and inactivation of LKB1 to promote lung cancer cell growth.
Zhu XN, He P, Zhang L, Yang S, Zhang HL, Zhu D, Liu MD, Yu Y
Cell death & disease 2019 Jun 19;10(7):486
Cell death & disease 2019 Jun 19;10(7):486
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.
Lignitto L, LeBoeuf SE, Homer H, Jiang S, Askenazi M, Karakousi TR, Pass HI, Bhutkar AJ, Tsirigos A, Ueberheide B, Sayin VI, Papagiannakopoulos T, Pagano M
Cell 2019 Jul 11;178(2):316-329.e18
Cell 2019 Jul 11;178(2):316-329.e18
FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21.
Zhang L, Chen J, Ning D, Liu Q, Wang C, Zhang Z, Chu L, Yu C, Liang HF, Zhang B, Chen X
Journal of experimental & clinical cancer research : CR 2019 Feb 26;38(1):101
Journal of experimental & clinical cancer research : CR 2019 Feb 26;38(1):101
Phosphorylation of BACH1 switches its function from transcription factor to mitotic chromosome regulator and promotes its interaction with HMMR.
Li J, Shima H, Nishizawa H, Ikeda M, Brydun A, Matsumoto M, Kato H, Saiki Y, Liu L, Watanabe-Matsui M, Iemura K, Tanaka K, Shiraki T, Igarashi K
The Biochemical journal 2018 Mar 15;475(5):981-1002
The Biochemical journal 2018 Mar 15;475(5):981-1002
F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells.
Wu B, Liu ZY, Cui J, Yang XM, Jing L, Zhou Y, Chen ZN, Jiang JL
International journal of molecular sciences 2017 Jan 20;18(1)
International journal of molecular sciences 2017 Jan 20;18(1)
Targeted inhibition of the COP9 signalosome for treatment of cancer.
Schlierf A, Altmann E, Quancard J, Jefferson AB, Assenberg R, Renatus M, Jones M, Hassiepen U, Schaefer M, Kiffe M, Weiss A, Wiesmann C, Sedrani R, Eder J, Martoglio B
Nature communications 2016 Oct 24;7:13166
Nature communications 2016 Oct 24;7:13166
Quantitative proteome analysis of age-related changes in mouse gastrocnemius muscle using mTRAQ.
Hwang CY, Kim K, Choi JY, Bahn YJ, Lee SM, Kim YK, Lee C, Kwon KS
Proteomics 2014 Jan;14(1):121-32
Proteomics 2014 Jan;14(1):121-32
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 13606-1-AP(FBXO22 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human tonsil using 13606-1-AP(FBXO22 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FBXO22 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FBXO22. This antibody recognizes human,mouse,rat antigen. The FBXO22 antibody has been validated for the following applications: ELISA, WB, IHC analysis.