CABT-L891

antibody from Creative Diagnostics
Targeting: BCL11B CTIP-2, CTIP2, hRIT1-alpha, ZNF856B
Provider product page for CABT-L891
Western blot
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
CABT-L891 - Provider product page
Provider
Creative Diagnostics
Product name
Rabbit Anti-Human BCL11B monoclonal antibody, clone KG10-01
Antibody type
Monoclonal
Description
Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Antibody clone number
KG10-01
Vial size
100 _l
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
BCL11B protein structure - CABT-L891 shown in red.