AGTO-L044S

antibody from Creative Biolabs

Targeting: ASTL ovastacin, SAS1B

Functional assay (Recommended by provider)

Antibody Data

Product number

AGTO-L044S

Provider

Creative Biolabs

Product name

anti-ASTL immunotoxin D-8 (Fab)-Sap

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-ASTL Fab to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to kidney cancer and pancreatic cancer cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of kidney cancer and pancreatic cancer.

Reactivity

Human

Host

Mouse

Antibody clone number

D-8