NCKAP1L

This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, May 2010]

Description

NCK associated protein 1 like

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Plasma membrane, Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (54497752 - 54548243)

Ensembl ID

ENSG00000123338  (ver. 103.38)

Orthologs

Mouse Nckap1l: ENSMUSG00000022488

UniProt

P55160

neXtProt

NX_P55160

Human splice variants
Mouse splice variants

Protein structure