FNab09196

antibody from FineTest Biotech
Targeting: UBQLN1 DA41, DSK2, PLIC-1, XDRP1
Provider product page for FNab09196
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
FNab09196 - Provider product page
Provider
FineTest Biotech
Product name
Ubiquilin 1 antibody
Antibody type
Polyclonal
Antigen
Recombinant protein fragment
Description
UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a?N-terminal?ubiquitin-like?domain?and a C-terminal ubiquitin-associated domain.?They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with?Alzheimer's?and?Parkinson's?disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP?(PMID: 21852239). This antibody detects 70kD band of UBQLN1.
Reactivity
Human, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
ubiquilin 1
Epitope
IgG
Isotype
IgG
Vial size
100¦Ìg
Concentration
Immunogen affinity purified
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
UBQLN1 protein structure - FNab09196 shown in red.