BS8158

antibody from Bioworld Technology, Inc
Targeting: CLIC1 CLCNL1, G6, NCC27, p64CLCP
Provider product page for BS8158
Western blot
Immunohistochemistry

Antibody data

Product number
BS8158 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CLIC1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CLIC1.
Description
Chloride intracellular channel 1 (CLIC1), also referred to as NCC27, is a member of the highly conserved family of chloride ion channels that function in both soluble and integral membrane forms. CLIC1 is a monomeric protein that contains a redox-active site similar to glutaredoxin; it functions as a anionselective channel. CLIC1 forms a dimer when oxidized and is then able to form chloride ion channels in bilayers and vesicles, whereas a reducing environment prevents this from occurring. Insulin concentration also plays a role in CLIC1 regulation, and the hormone may cause a subnuclear relocalization of CLIC1. CLIC1 is associated with macrophage activation; a downregulation of CLIC1 function prevents TNFÏ« release induced by ÉÇ-Amyloid protein (A-ÉÇ) stimulation. This suggests a role for CLIC1 in several neurodegenerative processes, such as Alzheimer£ªs disease, a syndrome characterized by an accumulation of A-ÉÇ.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CLIC1 protein structure - BS8158 shown in red.