Antibody data
- Antibody Data
- Antigen structure
- References [0]
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- Validations
- Western blot [1]
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- Product number
- BS8158 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CLIC1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human CLIC1.
- Description
- Chloride intracellular channel 1 (CLIC1), also referred to as NCC27, is a member of the highly conserved family of chloride ion channels that function in both soluble and integral membrane forms. CLIC1 is a monomeric protein that contains a redox-active site similar to glutaredoxin; it functions as a anionselective channel. CLIC1 forms a dimer when oxidized and is then able to form chloride ion channels in bilayers and vesicles, whereas a reducing environment prevents this from occurring. Insulin concentration also plays a role in CLIC1 regulation, and the hormone may cause a subnuclear relocalization of CLIC1. CLIC1 is associated with macrophage activation; a downregulation of CLIC1 function prevents TNFÏ« release induced by ÉÇ-Amyloid protein (A-ÉÇ) stimulation. This suggests a role for CLIC1 in several neurodegenerative processes, such as Alzheimer£ªs disease, a syndrome characterized by an accumulation of A-ÉÇ.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of CLIC1 polyclonal antibody