PTGER4

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

Description

Prostaglandin E receptor 4

Tissue specificity

Tissue enhanced (bone marrow, pancreas)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

5 (40679915 - 40693735)

Ensembl ID

ENSG00000171522  (ver. 103.38)

Orthologs

Mouse Ptger4: ENSMUSG00000039942

UniProt

P35408

neXtProt

NX_P35408

Human splice variants
Mouse splice variants

Protein structure