ABIN967740

antibody from antibodies-online

Targeting: SOS1 GF1, GINGF, HGF

Western blot (Data presented on provider website)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN967740

Provider

antibodies-online

Product name

anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) (AA 1-109) antibody

Antibody type

Monoclonal

Antigen

Mouse mSos1 aa. 1-109

Description

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Reactivity

Human, Mouse, Rat, Canine

Host

Mouse

Epitope

AA 1-109

Isotype

IgG

Antibody clone number

25-SOS1

Vial size

50 μg

Storage

Store undiluted at -20° C.

References

Submitted references

Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling.

Furuta S, Miura K, Copeland T, Shang WH, Oshima A, Kamata T
Oncogene 2002 Oct 10;21(46):7060-6

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Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes.

Kardinal C, Konkol B, Lin H, Eulitz M, Schmidt EK, Estrov Z, Talpaz M, Arlinghaus RB, Feller SM
Blood 2001 Sep 15;98(6):1773-81

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ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells.

Salojin KV, Zhang J, Meagher C, Delovitch TL
The Journal of biological chemistry 2000 Feb 25;275(8):5966-75

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor.

Buday L, Downward J
Cell 1993 May 7;73(3):611-20

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.

Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA
Nature 1993 May 6;363(6424):45-51