abx001822

antibody from Abbexa

Targeting: PDCD6IP AIP1, Alix, Hp95

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

abx001822

Provider

Abbexa

Product name

ALG-2-Interacting Protein X (PDCD6IP) Antibody

Antibody type

Polyclonal

Description

ALIX Antibody is a Rabbit Polyclonal antibody against ALIX. This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

3.76 mg/ml

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.