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antibody from antibodies-online
Targeting: FBXW7
AGO, CDC4, FBW7, FBX30, FBXW6, FLJ11071, SEL-10, SEL10
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- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- ABIN393696 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-708) antibody
- Antibody type
- Monoclonal
- Description
- This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Mouse
- Epitope
- AA 599-708
- Isotype
- IgG
- Antibody clone number
- 3D1
- Vial size
- 100 μg
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Submitted references Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL.
The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation.
The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation.
BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.
Erbilgin Y, Sayitoglu M, Hatirnaz O, Dogru O, Akcay A, Tuysuz G, Celkan T, Aydogan G, Salcioglu Z, Timur C, Yuksel-Soycan L, Ure U, Anak S, Agaoglu L, Devecioglu O, Yildiz I, Ozbek U
Disease markers 2010;28(6):353-60
Disease markers 2010;28(6):353-60
The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation.
Bengoechea-Alonso MT, Ericsson J
Proceedings of the National Academy of Sciences of the United States of America 2010 Jun 29;107(26):11817-22
Proceedings of the National Academy of Sciences of the United States of America 2010 Jun 29;107(26):11817-22
The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation.
Zhao D, Zheng HQ, Zhou Z, Chen C
Cancer research 2010 Jun 1;70(11):4728-38
Cancer research 2010 Jun 1;70(11):4728-38
BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.
Keutgens A, Zhang X, Shostak K, Robert I, Olivier S, Vanderplasschen A, Chapelle JP, Viatour P, Merville MP, Bex F, Gothot A, Chariot A
The Journal of biological chemistry 2010 Aug 13;285(33):25831-40
The Journal of biological chemistry 2010 Aug 13;285(33):25831-40
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Supportive validation
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- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
