CABT-RM101

antibody from Creative Diagnostics

Targeting: PDGFC fallotein, SCDGF

Western blot (Recommended by provider)

Antibody Data

Product number

CABT-RM101

Provider

Creative Diagnostics

Product name

Rabbit Anti-PDGFC polyclonal antibody

Antibody type

Polyclonal

Description

Platelet-derived growth factor C is encoded by the PDGFC gene in human. PDGF-C is a disulfide-linked homodimeric growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. It also plays an important role in wound healing and angiogenesis. It also serves as a potent mitogen and chemoattractant for cells of mesenchymal origin. It is synthesized with a signal peptide (aa 1-22), which is subsequently cleaved off in the mature form. Its CUB domain is localized to amino acids 46 to 163 and proteolytic removal of the CUB domain is essential for unmasking the receptor-binding epitopes of the core domain. PDGF-C is expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Its high expression is also reported in retinal pigment epithelia. In the kidney, it is constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells, and in arterial endothelial cells. Higher levels of PDGF-C and have been reported in the malignant breast tumor microenvironment. In MCF-7 cells increased expression of PDGF-C is reported to enhance cell proliferation and tumor cell motility. Tissue plasminogen activator and matriptase are shown to process PDGF-C in MCF-7 cells to its active form.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 _g, 25 _g

Storage

Stable for 1 year at 2-8°C from date of receipt.