GEMIN5

This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Description

Gem nuclear organelle associated protein 5

Tissue specificity

Low tissue specificity

Subcell location

Nuclear bodies, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (154887411 - 154938211)

Ensembl ID

ENSG00000082516  (ver. 103.38)

Orthologs

Mouse Gemin5: ENSMUSG00000037275

UniProt

Q8TEQ6

neXtProt

NX_Q8TEQ6

Human splice variants
Mouse splice variants

Protein structure