Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations [0]
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- Product number
- 27226-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- FTO antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FTO antibody (Cat. #27226-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Increased m6A-RNA methylation and FTO suppression is associated with myocardial inflammation and dysfunction during endotoxemia in mice.
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Downregulated fat mass and obesity-associated protein inhibits bone resorption and osteoclastogenesis by nuclear factor-kappa B inactivation.
Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression.
m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.
Decreased expression of m6A demethylase FTO in ovarian aging.
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis.
AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
The N6-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.
METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial-mesenchymal transition of renal tubular cells in diabetic kidney disease.
Increased m6A modification of RNA methylation related to the inhibition of demethylase FTO contributes to MEHP-induced Leydig cell injury☆.
Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.
Identification of a robust signature for clinical outcomes and immunotherapy response in gastric cancer: based on N6-methyladenosine related long noncoding RNAs.
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m6A RNA Methylation.
N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA.
Alteration of N6-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Resveratrol Attenuates Aflatoxin B1-Induced ROS Formation and Increase of m6A RNA Methylation.
FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.
Dubey PK, Patil M, Singh S, Dubey S, Ahuja P, Verma SK, Krishnamurthy P
Molecular and cellular biochemistry 2022 Jan;477(1):129-141
Molecular and cellular biochemistry 2022 Jan;477(1):129-141
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Downregulated fat mass and obesity-associated protein inhibits bone resorption and osteoclastogenesis by nuclear factor-kappa B inactivation.
Zhuang J, Ning H, Wang M, Zhao W, Jing Y, Liu X, Zu J, Kong P, Wang X, Sun C, Yan J
Cellular signalling 2021 Nov;87:110137
Cellular signalling 2021 Nov;87:110137
Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression.
Cheng L, Yu P, Li F, Jiang X, Jiao X, Shen Y, Lai X
Human cell 2021 Nov;34(6):1697-1708
Human cell 2021 Nov;34(6):1697-1708
m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.
Takemoto S, Nakano M, Fukami T, Nakajima M
Biochemical pharmacology 2021 Nov;193:114766
Biochemical pharmacology 2021 Nov;193:114766
Decreased expression of m6A demethylase FTO in ovarian aging.
Sun X, Zhang Y, Hu Y, An J, Li L, Wang Y, Zhang X
Archives of gynecology and obstetrics 2021 May;303(5):1363-1369
Archives of gynecology and obstetrics 2021 May;303(5):1363-1369
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis.
Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I
Molecular cell 2021 May 20;81(10):2076-2093.e9
Molecular cell 2021 May 20;81(10):2076-2093.e9
AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
Bian X, Shi D, Xing K, Zhou H, Lu L, Yu D, Wu W
Clinical and translational medicine 2021 Mar;11(3):e352
Clinical and translational medicine 2021 Mar;11(3):e352
The N6-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.
Ondo K, Isono M, Nakano M, Hashiba S, Fukami T, Nakajima M
Biochemical pharmacology 2021 Jul;189:114402
Biochemical pharmacology 2021 Jul;189:114402
METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial-mesenchymal transition of renal tubular cells in diabetic kidney disease.
Xu Z, Jia K, Wang H, Gao F, Zhao S, Li F, Hao J
Cell death & disease 2021 Jan 4;12(1):32
Cell death & disease 2021 Jan 4;12(1):32
Increased m6A modification of RNA methylation related to the inhibition of demethylase FTO contributes to MEHP-induced Leydig cell injury☆.
Zhao T, Wang J, Wu Y, Han L, Chen J, Wei Y, Shen L, Long C, Wu S, Wei G
Environmental pollution (Barking, Essex : 1987) 2021 Jan 1;268(Pt A):115627
Environmental pollution (Barking, Essex : 1987) 2021 Jan 1;268(Pt A):115627
Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.
Zhao S, Lu J, Chen Y, Wang Z, Cao J, Dong Y
Journal of reproductive immunology 2021 Aug;146:103341
Journal of reproductive immunology 2021 Aug;146:103341
Identification of a robust signature for clinical outcomes and immunotherapy response in gastric cancer: based on N6-methyladenosine related long noncoding RNAs.
Han T, Xu D, Zhu J, Li J, Liu L, Deng Y
Cancer cell international 2021 Aug 16;21(1):432
Cancer cell international 2021 Aug 16;21(1):432
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
Ma D, Liu X, Zhang JJ, Zhao JJ, Xiong YJ, Chang Q, Wang HY, Su P, Meng J, Zhao YB
Frontiers in cardiovascular medicine 2020;7:592550
Frontiers in cardiovascular medicine 2020;7:592550
Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m6A RNA Methylation.
Wu J, Li Y, Yu J, Gan Z, Wei W, Wang C, Zhang L, Wang T, Zhong X
Frontiers in pharmacology 2020;11:568006
Frontiers in pharmacology 2020;11:568006
N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.
Li Y, Xia L, Tan K, Ye X, Zuo Z, Li M, Xiao R, Wang Z, Liu X, Deng M, Cui J, Yang M, Luo Q, Liu S, Cao X, Zhu H, Liu T, Hu J, Shi J, Xiao S, Xia L
Nature genetics 2020 Sep;52(9):870-877
Nature genetics 2020 Sep;52(9):870-877
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.
Zhao L, Kong X, Zhong W, Wang Y, Li P
Pathology, research and practice 2020 Sep;216(9):153042
Pathology, research and practice 2020 Sep;216(9):153042
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA.
Gao XQ, Zhang YH, Liu F, Ponnusamy M, Zhao XM, Zhou LY, Zhai M, Liu CY, Li XM, Wang M, Shan C, Shan PP, Wang Y, Dong YH, Qian LL, Yu T, Ju J, Wang T, Wang K, Chen XZ, Wang YH, Zhang J, Li PF, Wang K
Nature cell biology 2020 Nov;22(11):1319-1331
Nature cell biology 2020 Nov;22(11):1319-1331
Alteration of N6-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.
Li X, Fan X, Yin X, Liu H, Yang Y
Epigenomics 2020 Jul;12(14):1157-1173
Epigenomics 2020 Jul;12(14):1157-1173
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.
Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C
Carcinogenesis 2020 Jul 10;41(5):541-550
Carcinogenesis 2020 Jul 10;41(5):541-550
Resveratrol Attenuates Aflatoxin B1-Induced ROS Formation and Increase of m6A RNA Methylation.
Wu J, Gan Z, Zhuo R, Zhang L, Wang T, Zhong X
Animals : an open access journal from MDPI 2020 Apr 13;10(4)
Animals : an open access journal from MDPI 2020 Apr 13;10(4)
FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.
Liu S, Huang M, Chen Z, Chen J, Chao Q, Yin X, Quan M
Experimental cell research 2020 Apr 1;389(1):111894
Experimental cell research 2020 Apr 1;389(1):111894
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