Tissue expression
Cell line expression
Protein structure
CLCN3
Chloride voltage-gated channel 3ClC-3, CLC3
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Top validated antibodies |
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GeneTex | GTX54815 | Polyclonal |
WB
ICC
IP
IHC |
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Novus Biologicals | 35810002 | 2 references | Polyclonal |
WB
EL |
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LSBio | LS-C432783 | Polyclonal |
WB
IHC |
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Biorbyt | orb1647 | Polyclonal |
WB
EL
ICC
IHC |
||
Antibodies Incorporated / NeuroMab | 73-259 | Monoclonal |
WB
ICC
IHC
|
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