Tissue expression
Cell line expression
Protein structure
POLG
DNA polymerase gamma, catalytic subunitPOLG1, POLGA
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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antibodies-online | ABIN954236 | 3 references | Polyclonal |
WB
EL
ICC
IHC
FC
|
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Abgent | AP14948B | Polyclonal |
WB
ICC
IHC
FC |
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Acris Antibodies GmbH | AP53379PU-N | Polyclonal |
WB
ICC
IHC
FC |
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NSJ Bioreagents | F54379 | Polyclonal |
WB
ICC
IHC
FC |
||
GeneTex | GTX100398 | Polyclonal |
WB
ICC
IP
IHC |
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Supportive data in Antibodypedia
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Recommended by provider