10-4116-25

antibody from ABEOMICS Inc.
Targeting: HLA-DRA HLA-DRA1
Provider product page for 10-4116-25

Antibody data

Product number
10-4116-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-HLADR Antibody
Antibody type
Monoclonal
Description
The HLA-DRA gene at 6p21.3 is one of the HLA class II alpha chain paralogues, and it plays a central role in the immune system by presenting peptides derived from extracellular proteins. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit is practically invariable. The promoter for the HLA-DRA is the most well studied, and it contains sites, from 5' to 3', for the trimeric RFX, CREB, the trimeric NF-Y, Oct-1, and YY1. RFX, CREB, and NF-Y contribute to the binding of the CIITA co-activator, which is either constitutively expressed in cells that constitutively express the MHC class II genes, or is induced by IFN-gamma activation of STAT1alpha. The beta-2 domain of the conserved HLA-DR alpha molecule encoded by the HLA-DRA1 locus interacts with the CD4 molecule in human lymphocytes. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
Human lymphoblastoid cell line was
used as an immunogen for this antib
ody.
Isotype
IgG
Antibody clone number
L243
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
HLA-DRA protein structure - 10-4116-25 shown in red.