11-8071

antibody from ABEOMICS Inc.

Targeting: NEUROG3 Atoh5, bHLHa7, Math4B, ngn3

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Product number: 11-8071 - Provider product page
Provider: ABEOMICS Inc.
Product name: Anti-Neurog 3/Ngn 3 Antibody
Antibody type: Polyclonal
Description: Neurog 3/Ngn 3 belongs to the bHLH (basic helix-loop-helix) class of transcription factors and functions primarily as an activator of gene transcription in endocrine progenitor cells. It is expressed in a small percentage of cells within the developing pancreas consisting of endocrine progenitor cells, and functions to directly enhance the expression of the lineage-committed transcription factors required for the differentiation of the endocrine progenitor cells into each of the endocrine cell subtypes. Ngn3 binds directly to the promoters of the beta -cell specific transcription factors beta2/NeuroD and Pax4 to promote the differentiation of progenitor cells into the b cell lineage. Ngn3 expression is extinguished coincident with the expression of the endocrine hormones that define the endocrine lineages, for example the insulin expression in beta cells. (21099270, 18599526)
Reactivity: Human
Host: Rabbit
Antigen sequence: Full length recombinant Ngn3 protei n was used as the immunogen for thi s antibody.
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing

NEUROG3 protein structure - 11-8071 shown in red.