Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 11-8071-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-Neurog 3/Ngn 3 Antibody
- Antibody type
- Polyclonal
- Description
- Neurog 3/Ngn 3 belongs to the bHLH (basic helix-loop-helix) class of transcription factors and functions primarily as an activator of gene transcription in endocrine progenitor cells. It is expressed in a small percentage of cells within the developing pancreas consisting of endocrine progenitor cells, and functions to directly enhance the expression of the lineage-committed transcription factors required for the differentiation of the endocrine progenitor cells into each of the endocrine cell subtypes. Ngn3 binds directly to the promoters of the beta -cell specific transcription factors beta2/NeuroD and Pax4 to promote the differentiation of progenitor cells into the b cell lineage. Ngn3 expression is extinguished coincident with the expression of the endocrine hormones that define the endocrine lineages, for example the insulin expression in beta cells. (21099270, 18599526)
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
Full length recombinant Ngn3 protei
n was used as the immunogen for thi
s antibody.- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
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- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Western blot analysis of Neurog 3/Ngn 3. Anti-Neurog 3/Ngn 3 antibody (11-8071) was used at 6 µg/ml on Liver lysate.