RXRB

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Description

Retinoid X receptor beta

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Cancer-related genes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Nuclear receptors
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

6 (33193588 - 33200665)

Ensembl ID

ENSG00000204231  (ver. 103.38)

Orthologs

Mouse Rxrb: ENSMUSG00000039656

UniProt

P28702

neXtProt

NX_P28702

Human splice variants
Mouse splice variants

Protein structure