UNC45B

This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Description

Unc-45 myosin chaperone B

Tissue specificity

Group enriched (heart muscle, skeletal muscle, tongue)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (35147817 - 35189345)

Ensembl ID

ENSG00000141161  (ver. 103.38)

Orthologs

Mouse Unc45b: ENSMUSG00000018845

UniProt

Q8IWX7

neXtProt

NX_Q8IWX7

Human splice variants
Mouse splice variants

Protein structure