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Cell line expression
Protein structure
NSD1
Nuclear receptor binding SET domain protein 1ARA267, FLJ22263, KMT3B, STO
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Sep 2018]
Top validated antibodies |
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| Invitrogen Antibodies |  PA5-50857 |
Polyclonal |
WB
ICC
IHC
ChIP
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| Novus Biologicals | H00064324-M08 |
1 references | Monoclonal |
WB
EL
IP
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| antibodies-online | ABIN151269 |
1 references | Polyclonal |
ICC
IHC
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| Abnova Corporation | H00064324-M08 |
1 references | Monoclonal |
EL
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| LSBio | LS-C286303 |
Polyclonal |
IHC
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