HTR2B

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

Description

5-hydroxytryptamine receptor 2B

Tissue specificity

Tissue enhanced (adrenal gland, cervix, endometrium , smooth muscle)

Subcell location

Nucleoplasm

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

2 (231108230 - 231125042)

Ensembl ID

ENSG00000135914  (ver. 103.38)

Orthologs

Mouse Htr2b: ENSMUSG00000026228

UniProt

P41595

neXtProt

NX_P41595

Human splice variants
Mouse splice variants

Protein structure