PADI3

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

Description

Peptidyl arginine deiminase 3

Tissue specificity

Group enriched (esophagus, urinary bladder)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (17249098 - 17284233)

Ensembl ID

ENSG00000142619  (ver. 103.38)

Orthologs

Mouse Padi3: ENSMUSG00000025328

UniProt

Q9ULW8

neXtProt

NX_Q9ULW8

Human splice variants
Mouse splice variants

Protein structure