Tissue expression
Cell line expression
Protein structure
B4GALT7
Beta-1,4-galactosyltransferase 7beta4Gal-T7, XGALT-1
This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome. [provided by RefSeq, Oct 2009]
Top validated antibodies |
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Novus Biologicals | NBP1-88652 | 1 references | Polyclonal |
WB
IHC |
|
Biorbyt | orb1217 | Polyclonal |
WB
EL
ICC
IHC |
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Proteintech Group | 10535-1-AP | 1 references | Polyclonal |
WB
EL |
|
Affinity Biosciences | DF9276 | Polyclonal |
WB
EL
IHC
|
||
LSBio | LS-C807805 | Polyclonal |
WB
EL
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider