POMZP3

This gene appears to have resulted from a fusion of DNA sequences derived from 2 distinct loci, specifically through the duplication of two internal exons from the POM121 gene and four 3' exons from the ZP3 gene. The 5' end of this gene is similar to the 5` coding region of the POM121 gene which encodes an integral nuclear pore membrane protein. However, the protein encoded by this gene lacks the nuclear pore localization motif. The 3' end of this gene is similar to the last 4 exons of the zona pellucida glycoprotein 3 (ZP3) gene and the encoded protein retains one zona pellucida domain. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

Description

POM121 and ZP3 fusion

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

7 (76609986 - 76627261)

Ensembl ID

ENSG00000146707  (ver. 103.38)

Orthologs

Mouse Zp3: ENSMUSG00000004948

UniProt

Q6PJE2

neXtProt

NX_Q6PJE2

Human splice variants
Mouse splice variants

Protein structure