APR01974G

antibody from Leading Biology

Targeting: MAS1

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APR01974G

Provider

Leading Biology

Product name

MAS1 / MAS Antibody (Cytoplasmic Domain)

Antibody type

Polyclonal

Description

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Reactivity

Human, Mouse, Bovine, Hamster, Porcine, Simian

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.