Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 14751-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14751-1-AP, RRID:AB_2156092
- Product name
- OSBPL2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OSBPL2 antibody (Cat. #14751-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references New label-free methods for protein relative quantification applied to the investigation of an animal model of Huntington Disease.
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability.
ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2).
Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis.
Identification of OSBPL2 as a novel candidate gene for progressive nonsyndromic hearing loss by whole-exome sequencing.
Cozzolino F, Landolfi A, Iacobucci I, Monaco V, Caterino M, Celentano S, Zuccato C, Cattaneo E, Monti M
PloS one 2020;15(9):e0238037
PloS one 2020;15(9):e0238037
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X
Experimental cell research 2019 Oct 15;383(2):111512
Experimental cell research 2019 Oct 15;383(2):111512
Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability.
Vivas O, Tiscione SA, Dixon RE, Ory DS, Dickson EJ
Cell reports 2019 May 28;27(9):2636-2648.e4
Cell reports 2019 May 28;27(9):2636-2648.e4
ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2).
Wang H, Ma Q, Qi Y, Dong J, Du X, Rae J, Wang J, Wu WF, Brown AJ, Parton RG, Wu JW, Yang H
Molecular cell 2019 Feb 7;73(3):458-473.e7
Molecular cell 2019 Feb 7;73(3):458-473.e7
Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis.
Escajadillo T, Wang H, Li L, Li D, Sewer MB
Molecular and cellular endocrinology 2016 May 15;427:73-85
Molecular and cellular endocrinology 2016 May 15;427:73-85
Identification of OSBPL2 as a novel candidate gene for progressive nonsyndromic hearing loss by whole-exome sequencing.
Xing G, Yao J, Wu B, Liu T, Wei Q, Liu C, Lu Y, Chen Z, Zheng H, Yang X, Cao X
Genetics in medicine : official journal of the American College of Medical Genetics 2015 Mar;17(3):210-8
Genetics in medicine : official journal of the American College of Medical Genetics 2015 Mar;17(3):210-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14751-1-AP(OSBPL2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The OSBPL2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human OSBPL2. This antibody recognizes human, mouse, rat antigen. The OSBPL2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.