H00065057-M02
antibody from Novus Biologicals
Targeting: ACD
Pip1, Ptop, Tint1, Tpp1
Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- ELISA [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- H00065057-M02 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#H00065057-M02, RRID:AB_536552
- Product name
- Mouse Monoclonal ACD Antibody
- Antibody type
- Monoclonal
- Description
- IgG purified. ACD - adrenocortical dysplasia homolog (mouse)
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references An N-terminal Flag-tag impairs TPP1 regulation of telomerase function.
Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.
The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.
Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1.
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
A ssDNA Aptamer That Blocks the Function of the Anti-FLAG M2 Antibody.
Characterization of the DNA binding specificity of Shelterin complexes.
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Sandhu R, Wei D, Sharma M, Xu L
Biochemical and biophysical research communications 2019 Apr 30;512(2):230-235
Biochemical and biophysical research communications 2019 Apr 30;512(2):230-235
Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.
Zanini IM, Soneson C, Lorenzi LE, Azzalin CM
Journal of cell science 2017 Feb 15;130(4):767-778
Journal of cell science 2017 Feb 15;130(4):767-778
The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.
Frank AK, Tran DC, Qu RW, Stohr BA, Segal DJ, Xu L
PLoS genetics 2015 Jul;11(7):e1005410
PLoS genetics 2015 Jul;11(7):e1005410
Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1.
Kocak H, Ballew BJ, Bisht K, Eggebeen R, Hicks BD, Suman S, O'Neil A, Giri N, NCI DCEG Cancer Genomics Research Laboratory, NCI DCEG Cancer Sequencing Working Group, Maillard I, Alter BP, Keegan CE, Nandakumar J, Savage SA
Genes & development 2014 Oct 1;28(19):2090-102
Genes & development 2014 Oct 1;28(19):2090-102
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR
Nature 2012 Dec 13;492(7428):285-9
Nature 2012 Dec 13;492(7428):285-9
A ssDNA Aptamer That Blocks the Function of the Anti-FLAG M2 Antibody.
Lakamp AS, Ouellette MM
Journal of nucleic acids 2011;2011:720798
Journal of nucleic acids 2011;2011:720798
Characterization of the DNA binding specificity of Shelterin complexes.
Choi KH, Farrell AS, Lakamp AS, Ouellette MM
Nucleic acids research 2011 Nov;39(21):9206-23
Nucleic acids research 2011 Nov;39(21):9206-23
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Abreu E, Aritonovska E, Reichenbach P, Cristofari G, Culp B, Terns RM, Lingner J, Terns MP
Molecular and cellular biology 2010 Jun;30(12):2971-82
Molecular and cellular biology 2010 Jun;30(12):2971-82
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- ELISA: ACD Antibody (1D8-1B6) [H00065057-M02] - Detection limit for recombinant GST tagged ACD is 0.3 ng/ml as a capture antibody.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunocytochemistry/Immunofluorescence: ACD Antibody (1D8-1B6) [H00065057-M02] - Analysis of monoclonal antibody to ACD on HeLa cell. Antibody concentration 10 ug/ml.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunoprecipitation: ACD Antibody (1D8-1B6) [H00065057-M02] - Analysis of ACD transfected lysate using anti-ACD monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with ACD MaxPab rabbit polyclonal antibody.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ACD Antibody (1D8-1B6) [H00065057-M02] - Analysis of monoclonal antibody to ACD on formalin-fixed paraffin-embedded human heart tissue. Antibody concentration 2 ug/ml.